The travel industry has traditionally been tough for emerging startups to crack since much of the data & tech was locked behind proprietary providers.   This has been changing the past several years, with a lot of travel providers opening up their own developer portals and API access to their services.
In a great article from TravelAndTransport on “How APIs are Positively Impacting the Travel Ecosystem”, they point out that:

“the travel industry is by nature, fragmented […] through the use of APIs, we are able to get real-time data […] and put that information at the fingertips of our travel counselors. The result is exactly what you’d expect – a more satisfying travel experience.”

Below is a brief review of some of the ones out there.

https://developer.singaporeair.com/

Singapore Airlines for Developers

https://developer.singaporeair.com/ "Get access to SIA's information and functionalities to improve your customers' experience. SIA has made this possible by developing ...
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https://developer.flightstats.com/

FlightStats API (by Cirium)

https://developer.flightstats.com/ "Cirium brings together powerful data and analytics to keep the world in motion. Diio Mi, QSI, FlightStats, Fleets Analyzer, ...
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https://www.developer.aero/

SITA Developer Aero

https://www.developer.aero/ "Mobile, web, tablet, kiosk, smart watch or whatever your technology medium, Developer.aero’s growing range of APIs enable you to ...
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https://developer.airfranceklm.com

Air France for Developers

https://developer.airfranceklm.com "Ready to land in our APIs? Connect directly to one of the biggest airline groups in Europe. Take a ...
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https://www.tripit.com/developer

TripIt API

https://www.tripit.com/developer TripIt is an open platform for integration and organization of travel information from many different sources. The TripIt API ...
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https://developer.airgateway.net/

AirGateway

https://developer.airgateway.net/ AirGateway provides a REST/JSON set of interfaces to NDC. Their developer access aggregates different providers such as BA, AF, ...
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